技术平台

Intelligent Protein Chip
智能蛋白芯片

蛋白质组芯片技术(人类、肺结核、新冠病毒)

得到Nature Methods期刊高度评价

作为经典案例入选美国化学会新冠技术特刊

  • 抗体组检测限可达到66.7aM
  • 动力学范围多达五个数量级
  • 芯片间重复性可达到0.99
  • 自行研发的三维表面化学、缓冲体系和质控体系可长期保持蛋白、 抗体和多肽等探针分子的生物活性
Trinity
三维一体组学平台
  • 外泌体组
    实现对肿瘤细胞释放的外泌体检测
  • 抗体组
    实现人体体液抗体的大规模检测
  • 蛋白质组
    实现体液蛋白质的检测
通过三维一体技术平台的打造,检测能力远远超过现有技术平台

相关文献

  • [1]Yu X, LaBaer J. High-throughput identification of proteins with AMPylation using self-assembled human protein (NAPPA) microarrays. Nat Protoc. 2015 May;10(5):756-67. doi: 10.1038/nprot.2015.044. Epub 2015 Apr 16. PMID: 25881200; PMCID: PMC4464792. 阅读全文
  • [2]Xu M, Xu K, Yin S, Chang C, Sun W, Wang G, Zhang K, Mu J, Wu M, Xing B, Zhang X, Han J, Zhao X, Wang Y, Xu D, Yu X. In-Depth Serum Proteomics Reveals the Trajectory of Hallmarks of Cancer in Hepatitis B Virus-Related Liver Diseases. Mol Cell Proteomics. 2023 Jul;22(7):100574. doi: 10.1016/j.mcpro.2023.100574. Epub 2023 May 19. PMID: 37209815; PMCID: PMC10316086. 阅读全文
  • [3]Cheng L, Wang D, Wang Z, et al. Proteomics landscape mapping of Organ‐Resolved behçet’s disease using In‐Depth plasma proteomics for identifying hyaluronic binding protein 2 expression associated with vascular involvement[J]. Arthritis & Rheumatology, 2023, 75(3): 424‒437. DOI:10.1002/art.42348. 阅读全文
  • [4]Wang H, Wu X, Zhang X, Hou X, Liang T, Wang D, Teng F, Dai J, Duan H, Guo S, Li Y, Yu X. SARS-CoV-2 Proteome Microarray for Mapping COVID-19 Antibody Interactions at Amino Acid Resolution. ACS Cent Sci. 2020 Dec 23;6(12):2238-2249. doi: 10.1021/acscentsci.0c00742. Epub 2020 Oct 21. PMID: 33372199; PMCID: PMC7586461. 阅读全文